کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
335209 546822 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
123I-ADAM SPECT imaging of serotonin transporter binding in patients with Night Eating Syndrome: A preliminary report
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
123I-ADAM SPECT imaging of serotonin transporter binding in patients with Night Eating Syndrome: A preliminary report
چکیده انگلیسی

Night eating syndrome (NES) represents a delay in the circadian pattern of food intake, manifested by evening hyperphagia and/or nocturnal awakenings accompanied by ingestions of food. A neurobiological marker of NES has been implicated with the recently discovered therapeutic response to the selective serotonin reuptake inhibitor (SSRI) sertraline. This pilot SPECT (single photon emission computed tomography) study compared the serotonin transporter (SERT) uptake ratios of night eaters with those of healthy controls. Six night eaters underwent SPECT imaging using the radiopharmaceutical 123I-ADAM. Uptake, compared with that of the cerebellum, was obtained for the midbrain, basal ganglia, and temporal lobes; uptake ratios in night eaters were compared with those of six healthy controls. Night eaters had significantly greater SERT uptake ratios in the midbrain than healthy controls. These findings, in conjunction with the therapeutic response of NES to sertraline, indicate that the serotonin system is involved in the pathophysiology of NES.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 162, Issue 3, 15 April 2008, Pages 214–220
نویسندگان
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