Generation and function of human regulatory CD8+ T cells induced by a humanized OKT3 monoclonal antibody hOKT3γ1(Ala-Ala)

Recent studies with a humanized anti-CD3 antibody in clinical trials suggested that this drug can induce regulatory CD8+ T cells. In this review, we discuss how these regulatory human CD8+ cells can be generated and the possible molecular tools they may use to inhibit immune responses. We compare our data on CD8+ regulatory cells induced by anti-CD3 stimulation with those reported in other experimental systems to identify both common and unique features of these cells.