کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3352408 1216481 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complete Sequencing of the HLA-A*68020102 Novel Allele Identified in Two Caucasoid Families
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Complete Sequencing of the HLA-A*68020102 Novel Allele Identified in Two Caucasoid Families
چکیده انگلیسی

We describe here the isolation and the full-length sequence of the coding region of the HLA new variant at the HLA-A locus officially named A*68020102. This variant shows an 11 base pairs deletion within the 5′ UTR region. The exon sequence is identical to that of A*6802 and the commercially available anti-A68 typing sera react with the antigen coded by the allele A*68020102.This variant was originally identified in two unrelated Caucasoid families because of discrepant HLA typing results between serology, Sequence Specific Oligonucleotide Probe (SSOP), and SBT. In fact, the A68 assigned by serology was undetectable with the molecular techniques. This has occurred because the deletion present in A*68020102 prevents specific amplification of HLA-A locus by some commercially available typing kits.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 68, Issue 3, March 2007, Pages 206–210
نویسندگان
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