کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3352549 | 1216488 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HLA-E*0101 allele in homozygous state favors severe bacterial infections in sickle cell anemia
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: HLA-E*0101 allele in homozygous state favors severe bacterial infections in sickle cell anemia HLA-E*0101 allele in homozygous state favors severe bacterial infections in sickle cell anemia](/preview/png/3352549.png)
چکیده انگلیسی
SummarySevere bacterial infections are the major causes of morbidity and mortality in sickle cell anemia (SCA) but are poorly explained. The distribution of a bi-allelic polymorphism (Arg107Gly) of human leukocyte antigen–E (HLA-E) locus was investigated in 144 SCA patients, most of whom originated from from sub-Saharan Africa. Among them, 73 presented with at least one severe bacterial infection, whereas 71 did not. The HLA-E*0101/E*0101 genotype was more frequent among the group with infections than their counterparts (47% vs 21%; p corrected = 0.003). This genetic association is of relevance, given the emerging evidence for the involvement of HLA-E molecules in host response to pathogens.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 68, Issue 10, October 2007, Pages 849–853
Journal: Human Immunology - Volume 68, Issue 10, October 2007, Pages 849–853
نویسندگان
Ryad Tamouza, Marc Busson, Catherine Fortier, Ibrahima Diagne, Dapa Diallo, Ivan Sloma, Hector Contouris, Rajagopal Krishnamoorthy, Dominique Labie, Robert Girot, Dominique Charron,