کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
335400 | 546955 | 2012 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Movement-related potentials point towards an impaired tuning of reafferent sensory feedback by preceding motor activation in schizophrenia Movement-related potentials point towards an impaired tuning of reafferent sensory feedback by preceding motor activation in schizophrenia](/preview/png/335400.png)
The link between focal motor system activation and reafferent sensory feedback is thought to be crucial for the perception that a movement is actively performed. In this article, we examine how schizophrenia affects the relationship between motor and somatosensory system activation. Movement-related potential source analysis allowed us to separate and compare motor activation deficits and reafferent feedback processing. We analyzed lateralized movement-related potentials during choice reaction movements in 16 subjects with schizophrenia/schizoaffective disorder. These subjects had partial remissions with predominantly negative symptoms and were compared to an age-matched healthy control group. In the schizophrenia/schizoaffective group, dipole source analysis indicated a significantly reduced lateralized sensorimotor activation immediately preceding movement execution. In contrast, activation by reafferent feedback was relatively unimpaired. Subjects with schizophrenia/schizoaffective disorder lacked a focal motor and reafferent sensory processing correlation, which can be identified through a significantly different regression slope from healthy controls. Reduced action-related motor system activation in subjects with schizophrenia/schizoaffective disorder was associated with preserved activation by reafferent sensory feedback. Most importantly, motor-sensory tuning, i.e. a specific enhancement of sensory information necessary to monitor movements, could not be found in subjects with schizophrenia/schizoaffective disorder. Our data provide further evidence for disturbed motor-sensory interactions in schizophrenia.
Journal: Psychiatry Research: Neuroimaging - Volume 202, Issue 1, 30 April 2012, Pages 65–73