کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
335495 546975 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alteration of spontaneous neuronal activity in young adults with non-clinical depressive symptoms
ترجمه فارسی عنوان
تغییرات فعالیت عصبی خود به خودی در بزرگسالان جوان با علائم افسردگی غیر بالینی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Reduced ALFF values were in right ventral lateral prefrontal cortex and dorsolateral prefrontal cortex in nCDSs subjects.
• Increased ALFF values in left posterior cerebellum, bilateral precuneus and other areas was found in nCDSs subjects.
• A positive correlation was found between Beck Depression Inventory scores and ALFF values in right DLPFC.
• A negative correlation was found between Beck Depression Inventory scores and ALFF values in left posterior cerebellum and bilateral precuneus.

Non-clinical depressive symptoms (nCDSs) are highly prevalent in young adults and may be associated with the risk of developing full-fledged depressive disorders. However, the neural basis underlying nCDSs remains unknown. To explore the alteration of spontaneous brain activity in individuals with nCDSs compared with healthy controls (HCs), we investigated resting-state brain activity using the amplitude of low-frequency fluctuations (ALFF) in subjects with nCDSs (n=17) and HCs (n=20). All subjects were drawn from a sample of 1105 college students participating in a survey assessing depressive symptoms. We determined that nCDSs can lead to reduced ALFF in the right ventral lateral prefrontal cortex (VLPFC) and right dorsolateral prefrontal cortex (DLPFC) and to increased ALFF in the left fusiform, left posterior cerebellum, right cuneus, left inferior parietal lobule, right supramarginal gyrus and bilateral precuneus. In addition, with respect to Beck Depression Inventory (BDI) scores and ALFF values in subjects with nCDSs, a positive correlation was discovered in the right DLPFC, while a negative correlation was identified in left posterior cerebellum and bilateral precuneus after correction. These results indicate that nCDSs are characterized by altered spontaneous activity in several important functional regions. We suggest that altered ALFFs in the right DLPFC, left posterior cerebellum and bilateral precuneus may be biomarkers that are related to the pathophysiology of nCDSs in young adults.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 233, Issue 1, 30 July 2015, Pages 36–42
نویسندگان
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