کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
335712 547016 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance
چکیده انگلیسی

Earlier studies with functional imaging in schizophrenia have demonstrated dysfunction of the dorsolateral prefrontal cortex during working memory. Controlling for behavioral performance and for catechol-O-methyltransferase (COMT) Val158Met genotype, we here demonstrate in a functional magnetic resonance imaging paradigm that patients recruit greater neuronal resources in prefrontal cortex during working memory, suggesting that this phenotype is a core functional trait of the disease. We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 147, Issues 2–3, 30 October 2006, Pages 221–226
نویسندگان
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