کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
335900 547049 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased serum androstenedione in adults with autism spectrum conditions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Increased serum androstenedione in adults with autism spectrum conditions
چکیده انگلیسی

SummaryMolecular and behavioural evidence points to an association between sex-steroid hormones and autism spectrum conditions (ASC) and/or autistic traits. Prenatal androgen levels are associated with autistic traits, and several genes involved in steroidogenesis are associated with autism, Asperger Syndrome and/or autistic traits. Furthermore, higher rates of androgen-related conditions (such as Polycystic Ovary Syndrome, hirsutism, acne and hormone-related cancers) are reported in women with autism spectrum conditions. A key question therefore is if serum levels of gonadal and adrenal sex-steroids (particularly testosterone, estradiol, dehydroepiandrosterone sulfate and androstenedione) are elevated in individuals with ASC. This was tested in a total sample of n = 166 participants. The final eligible sample for hormone analysis comprised n = 128 participants, n = 58 of whom had a diagnosis of Asperger Syndrome or high functioning autism (33 males and 25 females) and n = 70 of whom were age- and IQ-matched typical controls (39 males and 31 females). ASC diagnosis (without any interaction with sex) strongly predicted androstenedione levels (p < 0.01), and serum androstenedione levels were significantly elevated in the ASC group (Mann–Whitney W = 2677, p = 0.002), a result confirmed by permutation testing in females (permutation-corrected p = 0.02). This result is discussed in terms of androstenedione being the immediate precursor of, and being converted into, testosterone, dihydrotestosterone, or estrogens in hormone-sensitive tissues and organs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 36, Issue 8, September 2011, Pages 1154–1163
نویسندگان
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