کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3359583 1591832 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficacy of artemisinin in experimental visceral leishmaniasis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Efficacy of artemisinin in experimental visceral leishmaniasis
چکیده انگلیسی

Visceral leishmaniasis (VL), caused by the protozoan Leishmania sp., affects 500 000 people annually, with the Indian subcontinent contributing a significant proportion of these cases. Emerging refractoriness to conventional antimony therapy has emphasised the need for safer yet effective antileishmanial drugs. Artemisinin, a widely used antimalarial, demonstrated anti-promastigote activity and the 50% inhibitory concentration (IC50) ranged from 100 μM to 120 μM irrespective of Leishmania species studied. Leishmaniadonovani-infected macrophages demonstrated decreased production of nitrite as well as mRNA expression of inducible nitric oxide synthase, which was normalised by artemisinin, indicating that it exerted both a direct parasiticidal activity as well as inducing a host protective response. Furthermore, in a BALB/c model of VL, orally administered artemisinin (10 mg/kg and 25 mg/kg body weight) effectively reduced both splenic weight and parasite burden, which was accompanied by a restoration of Th1 cytokines (interferon-gamma and interleukin-2). Taken together, these findings have delineated the therapeutic potential of artemisinin in experimental VL.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 36, Issue 1, July 2010, Pages 43–49
نویسندگان
, , , ,