کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3360267 1591845 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacokinetic/pharmacodynamic modelling and in vitro simulation of dynamic voriconazole–Candida interactions
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Pharmacokinetic/pharmacodynamic modelling and in vitro simulation of dynamic voriconazole–Candida interactions
چکیده انگلیسی

Using dynamic time–kill experiments with changing voriconazole concentrations, it was demonstrated that Candida albicans ATCC 90029 as well as Candida glabrata and Candida parapsilosis clinical isolates (two each) were significantly inhibited by starting concentrations of 4× and 16× the minimum inhibitory concentration (MIC) but not 1× MIC. Time–kill data were accurately fitted using a sigmoidal Emax model. Pharmacokinetic (PK) parameters from human data sets were used in the model to simulate kill curves for typical treatment regimens. Simulated curves predicted that voriconazole would exert prolonged fungistatic activity against all five isolates. For three isolates, reductions from starting inocula over 60 h were predicted to exceed 2 log. Combining in vitro time–kill data with existing in vivo PK data might serve as an alternative to animal studies in defining optimal antifungal regimens.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 34, Issue 3, September 2009, Pages 240–245
نویسندگان
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