کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3360617 | 1591875 | 2008 | 6 صفحه PDF | دانلود رایگان |
The spectrum of chronic bacterial prostatitis (CBP) comprises Gram-negative, Gram-positive and atypical pathogens. Because of its broad spectrum of activity, moxifloxacin might be a suitable antibiotic for the treatment of CBP. In this pharmacokinetic study, plasma concentrations and the penetration of moxifloxacin into prostatic fluid and ejaculate were investigated. Twelve healthy male volunteers received a single oral dose of 400 mg moxifloxacin and at the same time received 3.24 g of iohexol intravenously to assess urinary contamination of prostatic fluid and ejaculate. Plasma concentrations were determined at 0, 0.5, 1, 2, 3 and 4 h and prostatic fluid and ejaculate (mean ± standard deviation (S.D.)) were determined at 3.5 ± 0.4 h and 3.6 ± 0.4 h, respectively, following administration of drugs. Urinary concentrations were determined in the urine collected from 0–4.5 h. Concentrations of moxifloxacin and iohexol in plasma, secretions and urine were determined by high-performance liquid chromatography. The mean ± S.D. peak plasma concentration of moxifloxacin was 2.8 ± 0.5 mg/L observed after 1.6 ± 0.9 h. In prostatic fluid, the concentration of moxifloxacin was 3.8 ± 1.2 mg/L and the prostatic fluid/plasma ratio was 1.6 ± 0.5. In ejaculate, the concentration was 2.5 ± 0.7 mg/L and the ejaculate/plasma ratio was 1.0 ± 0.2. Moxifloxacin concentrations in prostatic fluid were ca. 60% (P < 0.05) higher than in plasma and concentrations in ejaculate were approximately the same as in plasma. Therefore, moxifloxacin might be a good alternative for the treatment of CBP, but further studies are warranted to establish this indication.
Journal: International Journal of Antimicrobial Agents - Volume 31, Issue 1, January 2008, Pages 21–26