کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3360751 1591878 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibacterial resistance patterns in Streptococcus pneumoniae isolated from elderly patients: PROTEKT years 1–5 (1999–2004)
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Antibacterial resistance patterns in Streptococcus pneumoniae isolated from elderly patients: PROTEKT years 1–5 (1999–2004)
چکیده انگلیسی

The antibacterial susceptibilities of 6646 Streptococcus pneumoniae isolates collected in 38 countries from patients ≥65 years of age with community-acquired respiratory tract infections (RTIs) during years 1–5 of the PROTEKT study (1999–2004) were analysed. Rates of erythromycin resistance (36.0%), penicillin non-susceptibility (31.3%; 20.2% resistant plus 11.1% intermediately susceptible) and resistance to multiple antibacterials (37.2%) were stable over the 5 years. The most common macrolide resistance mechanism was erm(B) (61.4%); erm(B) + mef(A) strains increased from 5.4% (year 1) to 7.4% (year 5) (P = 0.037). Overall, 37.2% of isolates exhibited resistance to two or more antibacterials, including 15.9% resistant to both penicillin and erythromycin. Antibacterial resistance was highest in the Far East. Telithromycin resistance was rare (0.12%). Appropriate alternative empirical first-line therapies may be required for treating community-acquired RTIs in the elderly.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 30, Issue 6, December 2007, Pages 546–550
نویسندگان
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