کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3360793 1591879 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CG400462, a new bacterial enoyl–acyl carrier protein reductase (FabI) inhibitor
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
CG400462, a new bacterial enoyl–acyl carrier protein reductase (FabI) inhibitor
چکیده انگلیسی

CG400462, a novel FabI inhibitor, has a potent antibacterial activity against staphylococci. The minimal inhibitory concentration at which 90% of bacterial strains tested were inhibited (MIC90) of CG400462 was 0.5 μg/mL against 238 strains of Staphylococcus aureus and 1.0 μg/mL against 51 strains of coagulase-negative staphylococci, irrespective of whether the strains were methicillin-susceptible or -resistant. CG400462 was also effective by subcutaneous administration against systemic infections in mice. In time–kill studies, CG400462 at concentrations of 1×, 2× and 4× MIC had a bacteriostatic activity over 24 h. Genetic approaches have confirmed that the mode of action of CG400462 is via inhibition of FabI, which is involved in the biosynthesis of fatty acids in bacteria. Study of the resistance mechanism of S. aureus showed that CG400462-resistant mutants had an alteration in FabI of Met99 → Thr or Tyr147 → His.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 30, Issue 5, November 2007, Pages 446–451
نویسندگان
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