کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3360836 1591873 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cell wall deficiency and its effect on methicillin heteroresistance in Staphylococcus aureus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Cell wall deficiency and its effect on methicillin heteroresistance in Staphylococcus aureus
چکیده انگلیسی

Clinical strains of Staphylococcus aureus with different phenotypic methicillin susceptibility characteristics, bearing or lacking the mecA gene, were tested for their ability to transform into a cell wall-deficient state under special conditions of cultivation. Conversion to L-form growth with formation of typical L-form ‘fried egg’ colonies and expression of oxacillin resistance was observed in sensitive (mecA-negative) and heteroresistant (mecA-positive) strains. Transmission electron microscopy observation of these strains revealed pleomorphic populations of cell wall-deficient cells with ultrastructure morphology similar to that of a control stable L-form strain of S. aureus. The results demonstrate that expression of phenotypic methicillin resistance could be associated with cell wall deficiency in S. aureus strains and could underlie the phenomenon of heteroresistance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 31, Issue 3, March 2008, Pages 255–260
نویسندگان
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