کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3360909 1591880 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Peritoneal penetration and pharmacodynamic exposure of intravenous cefozopran in abdominal surgery patients
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Peritoneal penetration and pharmacodynamic exposure of intravenous cefozopran in abdominal surgery patients
چکیده انگلیسی

This study aimed to examine the peritoneal penetration and pharmacodynamic exposure of intravenous cefozopran. Cefozopran 1 g was administered to 10 patients before abdominal surgery. Venous blood and peritoneal fluid (PF) samples were obtained at the end of the 0.5-h infusion and at 1, 2, 3, 4, 5 and 6 h thereafter. Drug concentrations in plasma and PF were determined, analysed pharmacokinetically and used for a Monte Carlo simulation with minimum inhibitory concentration (MIC) data. Cefozopran penetrated well into PF, with a mean (±standard deviation) maximum drug concentration in PF/plasma ratio of 0.65 ± 0.17 (n = 10) and area under the concentration–time curve ratio of 0.92 ± 0.13. The probabilities of attaining the pharmacodynamic exposure target (PTA), defined as 70% of the time above the MIC, in PF were almost identical to those in plasma. The PTAs were 95–100% against Escherichia coli, Enterobacter spp. and Staphylococcus aureus with 0.5 g every 12 h; however, 1 g every 8 h or 1 g every 6 h was required for 93–98% PTA against Pseudomonas aeruginosa. These results should help us to understand the peritoneal pharmacokinetics of cefozopran whilst also helping to choose the appropriate dosage for surgical intra-abdominal infections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 30, Issue 4, October 2007, Pages 352–355
نویسندگان
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