کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3360910 1591880 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ertapenem for the treatment of extended-spectrum β-lactamase-producing Gram-negative bacterial infections
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Ertapenem for the treatment of extended-spectrum β-lactamase-producing Gram-negative bacterial infections
چکیده انگلیسی

Ertapenem is indicated for complicated intra-abdominal, skin and skin-structure, urinary tract and acute pelvic infections as well as community-acquired pneumonia, for which there are cheaper and more narrow-spectrum antibiotics. It is active against extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacteria, but report of its clinical efficacy is lacking. We evaluated our experience with the use of ertapenem for ESBL-producing Gram-negative bacterial infections over 13 months. Forty-seven patients were treated with 50 courses of ertapenem. Thirty-nine courses were for ESBL-producing Gram-negative bacterial infections, 33% of which were bacteraemia. The clinical response rate was 92% and survival to hospital discharge was 94%. We propose that ertapenem has a role in the first-line treatment of these infections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 30, Issue 4, October 2007, Pages 356–359
نویسندگان
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