کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3360928 1591874 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ciprofloxacin and furagin in acute cystitis: comparison of early immune and microbiological results
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Ciprofloxacin and furagin in acute cystitis: comparison of early immune and microbiological results
چکیده انگلیسی

Furagin (a nitrofurantoin analogue) has the same efficacy in treating acute cystitis as ciprofloxacin, however the duration of therapy is longer. We established a hypothesis that therapy with ciprofloxacin results in faster resolution of mucosal inflammation in comparison with furagin. Rates of urinary secretion of immunoglobulins class A, M and G and interleukin-8 (IL-8) were evaluated before and after initiation of therapy in adult women presenting with acute cystitis confirmed by urine culture. Women were randomised into two groups receiving either ciprofloxacin 250 mg twice a day for 3 days (n = 13) or furagin 100 mg three times a day for 7 days (n = 14). Median lengths of follow-up were 4 days and 5 days in the ciprofloxacin and furagin groups, respectively. Treatment with ciprofloxacin resulted in faster eradication of pathogens. No bacteria or nitrates were detected in the ciprofloxacin group, whilst leukocyte esterase was positive in only one case. In the furagin group there were four positive cultures, seven cases with positive nitrates and five cases with positive esterase. Secretion rates of all four substances dropped significantly, but the changes over time were similar in both groups.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 31, Issue 2, February 2008, Pages 130–134
نویسندگان
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