کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3361199 | 1591887 | 2007 | 10 صفحه PDF | دانلود رایگان |
We report here on the activity of tigecycline and comparators against multidrug-resistant (resistant to ≥3 antimicrobial classes; MDR) Enterobacteriaceae from the USA collected between January 2004 and January 2006 as part of the Tigecycline Evaluation and Surveillance Trial (TEST). Nationally, 131 (5.9%) Escherichia coli, 174 (10.1%) Klebsiella pneumoniae, 4 (1.2%) Klebsiella oxytoca, 24 (4.9%) Enterobacter aerogenes, 126 (9.5%) Enterobacter cloacae and 20 (2.6%) Serratia marcescens isolates were MDR. Four isolates (two K. pneumoniae and two E. cloacae) were resistant to nine antimicrobials. Tigecycline performed well against MDR E. coli (MIC90 0.5 μg/mL, 0% resistant) and K. pneumoniae (MIC90 4 μg/mL, 9.2% resistant). A MIC90 of 8 μg/mL was reported for tigecycline against the other MDR organisms studied here, notably lower than those of most comparators.
Journal: International Journal of Antimicrobial Agents - Volume 29, Issue 5, May 2007, Pages 518–527