کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3362203 1592063 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them
ترجمه فارسی عنوان
درک اثربخشی داروهای ضد سل: تفکر جمعیت باکتری ها و نحوه مدل سازی آنها
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی


• We review the different Mycobacterium tuberculosis subpopulations that persist during drug therapy.
• Evaluate in vitro and in vivo models available to study these subpopulations.
• Propose future research towards the consideration of M.tb population heterogeneity during drug development.

Tuberculosis still remains a global health emergency, claiming 1.5 million lives in 2013. The bacterium responsible for this disease, Mycobacterium tuberculosis (M.tb), has successfully survived within hostile host environments, adapting to immune defence mechanisms, for centuries. This has resulted in a disease that is challenging to treat, requiring lengthy chemotherapy with multi-drug regimens. One explanation for this difficulty in eliminating M.tb bacilli in vivo is the disparate action of antimicrobials on heterogeneous populations of M.tb, where mycobacterial physiological state may influence drug efficacy. In order to develop improved drug combinations that effectively target diverse mycobacterial phenotypes, it is important to understand how such subpopulations of M.tb are formed during human infection. We review here the in vitro and in vivo systems used to model M.tb subpopulations that may persist during drug therapy, and offer aspirations for future research in this field.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Infectious Diseases - Volume 32, March 2015, Pages 76–80
نویسندگان
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