کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3362474 | 1592072 | 2014 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: An outbreak of aseptic meningitis caused by a distinct lineage of coxsackievirus B5 in China An outbreak of aseptic meningitis caused by a distinct lineage of coxsackievirus B5 in China](/preview/png/3362474.png)
SummaryIn 2009, an outbreak of aseptic meningitis caused by coxsackievirus B5 (CVB5) occurred in China. Epidemiological investigations of this outbreak revealed that the proportion of severe cases (14/43, 33%) was higher than in other outbreaks associated with CVB5 in China. Phylogenetic analysis of the entire VP1 sequences demonstrated that the CVB5 isolates from the severe cases form a distinct lineage belonging to genogroup E with the Shandong isolates of 2009. A substitution of serine (S) to asparagine (N) at amino acid 95 in the VP1 region may be a major virulence determinant for the virus. Our findings suggest that this new lineage of CVB5 is circulating in China. Further genetic studies are needed in order to gain a better insight into the genetic variability of CVB5 isolates and the relationship with pathogenicity.
Journal: International Journal of Infectious Diseases - Volume 23, June 2014, Pages 101–104