کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
336250 547093 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Absence of a normal Cortisol Awakening Response (CAR) in adolescent males with Asperger Syndrome (AS)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Absence of a normal Cortisol Awakening Response (CAR) in adolescent males with Asperger Syndrome (AS)
چکیده انگلیسی

SummaryIn addition to abnormalities in social and communication development, a ‘need for sameness’ and ‘resistance to change’ are features of autistic spectrum disorders first identified by Kanner in 1943. Our ability to react to change is modulated by the hypothalamic–pituitary–adrenal (HPA) axis, a feature of which is a dramatic increase in cortisol upon waking, the Cortisol Awakening Response (CAR). This study examined whether the CAR was evident in 20 adolescent males with Asperger Syndrome (AS) and 18 age-matched typically developing (TD) controls (aged 11–16). Whilst a significant CAR was evidenced in the TD control group, this was not the case for those with AS. A normal diurnal decrease in cortisol, however, was evident in both groups. The implication that individuals with AS may have an impaired response to change in their environment due to a refractory HPA axis is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 34, Issue 7, August 2009, Pages 1095–1100
نویسندگان
, , , ,