کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3363051 1592113 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Invasive Haemophilus influenzae in British Columbia: non-Hib and non-typeable strains causing disease in children and adults
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Invasive Haemophilus influenzae in British Columbia: non-Hib and non-typeable strains causing disease in children and adults
چکیده انگلیسی

SummaryObjectivesTo characterize invasive Haemophilus influenzae and to examine the population at risk for invasive H. influenzae disease in British Columbia, Canada, 2008–2009.MethodsH. influenzae recovered from individual patients were characterized by serotyping, biotyping, multilocus sequence typing (MLST), and antibiotic susceptibility testing. Age information was recorded from specimen requisition forms.ResultsOf the 98 cases, 66% were caused by non-typeable strains, followed by serotypes b (12%), a (10%), f (10%), and e (1%). Cases caused by serotypes b and f and non-typeable strains were mainly in adults over 18 years of age, while cases due to serotype a were mainly in children under the age of 2 years. Different sequence types were found in encapsulated strains according to their serotypes, and non-typeable strains had their own unique sequence types. No capsule switching was documented. Antibiotic resistance was common among non-typeable strains, with 31% identified as genotypic β-lactamase-negative ampicillin-resistant (BLNAR) strains.ConclusionInvasive H. influenzae disease in a population vaccinated against Hib was age-dependent and involved both non-typeable and encapsulated strains. Adults were susceptible to invasive diseases due to non-typeable and serotype b and f strains, while in children, most diseases were due to serotype a bacteria.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Infectious Diseases - Volume 15, Issue 3, March 2011, Pages e167–e173
نویسندگان
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