کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3363278 1592104 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prognosis of acute invasive fungal rhinosinusitis related to underlying disease
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Prognosis of acute invasive fungal rhinosinusitis related to underlying disease
چکیده انگلیسی

SummaryBackgroundAcute invasive fungal rhinosinusitis (AIFRS) is a rare disease with high morbidity and mortality rates. The objective of this study was to correlate the initial clinical features of AIFRS to the prognosis after surgery.MethodsThirty-two patients with AIFRS were evaluated retrospectively. The correlation of underlying disease, fungus isolated, and extent of the disease to the clinical outcome of AIFRS was also evaluated.ResultsThe most common underlying disease was hematological malignancy and aplasia (n = 20). Aspergillus (n = 13) and Mucoraceae (n = 11) were the main fungi found in AIFRS. Mucosal biopsy confirmed fungal invasion to the nasal mucosa in all cases. Computed tomography and endoscopic findings showed a predominance of unilateral disease, with various stages of nasal involvement. All patients underwent surgical debridement and systemic antifungal therapy immediately after diagnosis. Sixteen patients died (50%) due to AIFRS. A poor prognosis was related to the extensiveness of AIFRS and to the underlying disease (patients with aplastic anemia and diabetes had the worst outcomes), but not to the fungus isolated.ConclusionsEarly medical and surgical treatment is essential to improve the prognosis of AIFRS patients. A poorer prognosis was associated with underlying disease and extensiveness of AIFRS, but not to the fungus isolated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Infectious Diseases - Volume 15, Issue 12, December 2011, Pages e841–e844
نویسندگان
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