کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3363430 | 1592153 | 2007 | 7 صفحه PDF | دانلود رایگان |
SummaryPlasmid-mediated class C β-lactamases are reported from Enterobacteriaceae with increasing frequency. They likely originate from chromosomal AmpC of certain Gram-negative bacterial species and subsequently are mobilized onto transmissible plasmids. There are reports of unfavorable clinical outcomes in patients infected with these organisms and treated with broad-spectrum cephalosporins. However, unlike class A extended-spectrum β-lactamases (ESBLs), no screening and confirmatory tests have been uniformly established for strains that produce class C β-lactamases. Reduced susceptibility to cefoxitin is a sensitive but not specific indicator of class C β-lactamase production. Simple confirmatory tests including tests using boronic acid compounds as specific class C β-lactamase inhibitors have recently been developed. Their utilization will enable clinical microbiology laboratories to report those strains producing plasmid-mediated class C β-lactamases as being resistant to all broad-spectrum cephalosporins, thus allowing physicians to prescribe appropriate antimicrobial therapy.
Journal: International Journal of Infectious Diseases - Volume 11, Issue 3, May 2007, Pages 191–197