کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3364508 1592134 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Invasive fungal infections and (1,3)-β-d-glucan serum concentrations in long-term intensive care patients
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Invasive fungal infections and (1,3)-β-d-glucan serum concentrations in long-term intensive care patients
چکیده انگلیسی

SummaryObjectiveInvasive fungal infections are associated with high morbidity and increased mortality. This study was performed to assess the epidemiology of fungal infections and to determine (1,3)-β-d-glucan serum concentrations in patients admitted to intensive care units (ICUs).Patients and methodsOverall 197 patients were admitted to nine medical and surgical intensive care units (ICUs) at a 2200-bed university hospital during a 3-month period. Retrospectively, the patients were split into three groups: group A comprised 24 patients with proven invasive fungal infections admitted for a median of 40 days. Group B comprised 58 patients who were admitted to the ICU for 30 days but without fungal infection. One hundred and fifteen post-operative patients served as controls (group C). The levels of (1,3)-β-d-glucan were monitored in all patients twice weekly during their ICU admittance.ResultsAverage (1,3)-β-d-glucan concentrations were significantly higher in the patients with fungal infections compared to group B and group C (median 44 vs. 22 and 12.9 pg/ml, respectively; p < 0.001). For a serum (1,3)-β-D-glucan level of 40 pg/ml, the sensitivity, the specificity, the positive predictive value, the negative predictive value, the area under the curve of the receiver operating characteristics (AUC ROC) curve, the likelihood ratio (LR)+ and LR− were 52.2, 75.9, 46.2, 80, 0.7, 2.16, and 0.63, respectively, on day 7. Patients in group A had bacterial infections significantly more often than patients in group B (p = 0.003). The hospitalization before ICU admittance for group A was significantly longer than for groups B and C (median 19 (group A) vs. 6 (group B) vs. 10 (group C) days; p < 0.05).ConclusionsLonger hospitalization and multiple bacterial infections were found to be the main risk factors for invasive fungal infections. Long-term ICU patients have elevated (1,3)-β-d-glucan levels, not only due to invasive fungal infections, but also due to the serious underlying diseases and conditions, inter-current complications, and intensive care measures. Yet, persistently high serum levels of (1,3)-β-d-glucan in ICU patients may be indicative of invasive fungal infections and warrant additional diagnostic efforts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Infectious Diseases - Volume 13, Issue 6, November 2009, Pages 707–712
نویسندگان
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