کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
336490 547148 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glucocorticoid and mineralocorticoid receptor polymorphisms and clinical characteristics in bipolar disorder patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Glucocorticoid and mineralocorticoid receptor polymorphisms and clinical characteristics in bipolar disorder patients
چکیده انگلیسی

SummaryIntroductionThe hypothalamus–pituitary–adrenal (HPA)-axis is often found to be dysregulated in bipolar disorder (BD) while stress and changes in day–night rhythms can trigger a new mood episode. Genetic variants of the glucocorticoid receptor (GR)- and mineralocorticoid receptor (MR)-gene influence both the reactivity of the stress–response and associate with changes in mood. In this study we tested the hypothesis that these polymorphisms associate with different clinical characteristics of BD.MethodsWe studied 326 outpatients with BD and performed GR genotyping of the TthIIII, ER22/23EK, N363S, BclI, and 9β polymorphisms, as well as MR genotyping of the 2G/C and I180V variants. All patients were interviewed for clinical characteristics.ResultsSeasonal patterns of hypomania are related to the BclI haplotype and the TthIIII + 9β haplotype of the GR gene (respectively, crude p = .007 and crude p = .005). Carriers of the ER22/23EK polymorphism had an almost 8 years earlier onset of their first (hypo)manic episode than non-carriers (crude p = .004, after adjustment p = .016). No evidence for a role of the MR in modifying clinical manifestations was found.ConclusionPolymorphisms of the GR-gene are factors which influence some clinical manifestations of BD, with respect to seasonal pattern of (hypo)mania and age of onset.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 36, Issue 10, November 2011, Pages 1460–1469
نویسندگان
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