کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
336542 547157 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No association between oxytocin or prolactin gene variants and childhood-onset mood disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
No association between oxytocin or prolactin gene variants and childhood-onset mood disorders
چکیده انگلیسی

SummaryBackgroundOxytocin (OXT) and prolactin (PRL) are neuropeptide hormones that interact with the serotonin system and are involved in the stress response and social affiliation. In human studies, serum OXT and PRL levels have been associated with depression and related phenotypes. Our purpose was to determine if single nucleotide polymorphisms (SNPs) at the loci for OXT, PRL and their receptors, OXTR and PRLR, were associated with childhood-onset mood disorders (COMD).MethodsUsing 678 families in a family-based association design, we genotyped 16 SNPs at OXT, PRL, OXTR and PRLR to test for association with COMD.ResultsNo significant associations were found for SNPs in the OXTR, PRL, or PRLR genes. Two of three SNPs 3′ of the OXT gene were associated with COMD (p ≤ 0.02), significant after spectral decomposition, but were not significant after additionally correcting for the number of genes tested. Supplementary analyses of parent-of-origin and proband sex effects for OXT SNPs by Fisher's Exact test were not significant after Bonferroni correction.ConclusionsWe have examined 16 OXT and PRL system gene variants, with no evidence of statistically significant association after correction for multiple tests.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 35, Issue 9, October 2010, Pages 1422–1428
نویسندگان
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