کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3365569 1218372 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Usefulness of intra-articular botulinum toxin injections. A systematic review
ترجمه فارسی عنوان
مفید بودن تزریق سم بوتولینوم داخل مفصلی. بررسی سیستماتیک
کلمات کلیدی
سم بوتولینوم، تزریق داخل مفصلی، آرتروز، کپسولیت چسبیده شانه، روماتولوژی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
چکیده انگلیسی

Botulinum toxin is a proven and widely used treatment for numerous conditions characterized by excessive muscular contractions. Recent studies have assessed the analgesic effect of botulinum toxin in joint pain and started to unravel its mechanisms.Literature-search-methodologyWe searched the international literature via the Medline database using the term “intraarticular botulinum toxin injection” combined with any of the following terms: “knee”, “ankle”, “shoulder”, “osteoarthritis”, “adhesive capsulitis of the shoulder”.ResultsOf 16 selected articles about intraarticular botulinum toxin injections, 7 were randomized controlled trials done in patients with osteoarthritis, adhesive capsulitis of the shoulder, or chronic pain after joint replacement surgery. Proof of anti-nociceptive effects was obtained in some of these indications and the safety and tolerance profile was satisfactory. The studies are heterogeneous. The comparator was usually a glucocorticoid or a placebo; a single study used hyaluronic acid. Pain intensity was the primary outcome measure.Discussion-conclusionThe number of randomized trials and sample sizes are too small to provide a satisfactory level of scientific evidence or statistical power. Unanswered issues include the effective dosage and the optimal dilution and injection modalities of botulinum toxin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Joint Bone Spine - Volume 83, Issue 2, March 2016, Pages 149–154
نویسندگان
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