کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3366112 | 1218392 | 2012 | 4 صفحه PDF | دانلود رایگان |
ObjectiveThis study aimed to evaluate remission in patients with early RA treated by conventional DMARDs and to identify its possible predictor factors.MethodsPatients with early RA (< 12 months) were enrolled in a 2-year follow-up study. Standard evaluation completed at baseline and at 24 months included clinical, laboratory, functional and structural assessment. Clinical remission after 2 years of follow-up was defined when DAS28 was less than 2.6. Possible predictor factors for remission were analyzed.ResultsFifty-one patients (88.2% women, mean age of 46.9 [24–72] years, mean disease duration of 24 [6–48] weeks) were enrolled in this study. The delay in referral for specialist care was 140 [7–420] days. Rheumatoid factor, anti-CCP, HLA-DRB1*01 and DRB1*04 alleles were present respectively in 62.5, 56.6, 11.8, and 45.1% of patients. At 24 months, 77.2% received a median dose of 5 (0–8) mg/day of prednisone and 65.2% was taking methotrexate (MTX). 13.6% of patients had stopped their DMARD because of socioeconomic difficulties. At 24 months, we noted a significant improvement of morning stiffness, pain score, swollen joint count, ESR, CRP, DAS28 and HAQ scores. Remission at 2 years was noted in 34.8% of patients and was significantly associated in univariate but not in multivariate analysis to male sex (P = 0.02) and to short delay in referral for specialist (P = 0.03).ConclusionIn this cohort of early RA patients treated with conventional DMARDs, especially with methotrexate in monotherapy, remission at 2-year of follow-up was obtained in one third of patients. No predictor factors of remission were found out. These results should be verified by further studies.
Journal: Joint Bone Spine - Volume 79, Issue 1, January 2012, Pages 43–46