کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
336639 547179 2010 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Agonistic behavior in males and females: Effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Agonistic behavior in males and females: Effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice
چکیده انگلیسی

SummaryAffiliative and agonistic social interactions are mediated by gonadal hormones. Research with estrogen receptor alpha (ERα) or beta (ERβ) knockout (KO) mice show that long-term inactivation of ERα decreases, while inactivation of ERβ increases, male aggression. Opposite effects were found in female αERKO and βERKO mice. The role of acute activation of ERα or ERβ in the agonistic responses of adult non-KO mice is unknown. We report here the effects of the ERβ selective agonist WAY-200070 on agonistic and social behavior in gonadally intact and gonadectomized (gonadex) male and female CD-1 mice towards a gonadex, same-sex intruder. All 15 min resident–intruder tests were videotaped for comprehensive behavioral analysis. Separate analyses assessed: (1) effects of WAY-200070 on each sex and gonadal condition; (2) differences between sexes, and between gonadally intact and gonadex mice, in untreated animals. Results show that in gonadally intact male and female mice, WAY-200070 increased agonistic behaviors such as pushing down the intruder and aggressive grooming, while leaving attacks unaffected. In untreated mice, males attacked more than females, and gonadex animals showed less agonistic behavior than same-sex, gonadally intact mice. Overall, our detailed behavioral analysis suggested that in gonadally intact male and female mice, ERβ mediates patterns of agonistic behavior that are not directly involved in attacks. This suggests that specific aspects of aggressive behavior are acutely mediated by ERβ in adult mice. Our results also showed that, in resident–intruder tests, female mice spend as much time in intrasexual agonistic interactions as males, but use agonistic behaviors that involve extremely low levels of direct attacks. This non-attack aggression in females is increased by acute activation of ERβ. Thus, acute activation of ERβ similarly mediates agonistic behavior in adult male and female CD-1 mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 35, Issue 7, August 2010, Pages 1008–1022
نویسندگان
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