کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3373471 | 1219297 | 2008 | 10 صفحه PDF | دانلود رایگان |
SummaryFrom April 1996 to July 2004, an outbreak of metallo-β-lactamase-positive (MBL) Pseudomonas aeruginosa occurred in the haematology ward at Nantes University Hospital in France. Fifty-nine patients were carriers of VIM-2-positive strains of whom 14 were infected (mostly urinary tract infections and pneumonia). Pulsed-field gel electrophoresis identified related isolates demonstrating resistance to all β-lactams, aminoglycosides, fluoroquinolones, fosfomycin, rifampicin but not colistin. The blaVIM-2 gene responsible for VIM-2 MBL was not plasmid-encoded but part of a novel type of class 1 integron. VIM-2-positive strains were mostly from urine samples and clinical data suggest that in the absence of therapeutic guidelines, piperacillin–tazobactam or aztreonam may be a reliable choice for treating infections with MBL-producing strains.
Journal: Journal of Hospital Infection - Volume 68, Issue 1, January 2008, Pages 73–82