کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
337399 547537 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Health Canada Warning on Citalopram and Escitalopram—Its Effects on Prescribing in Consultation-Liaison Psychiatry
ترجمه فارسی عنوان
هشدار اداره سلامت کانادا در سیتالوپرام و اسیتالوپرام؛ اثرات آن بر تجویز در روانپزشکی رابط مشاوره
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی

BackgroundReports have suggested that citalopram and escitalopram may prolong the QTc interval, leading Health Canada to issue a warning to limit their dosages in 2012. Little is known about the effects of this warning and similar ones (e.g., by the Food and Drug Administration) on antidepressant prescribing in inpatients with acute medical illness, who are theoretically at high risk of QTc prolongation. The main objective of our study is to examine the effect of the Health Canada warning on citalopram/escitalopram prescribing patterns in the consultation-liaison (C-L) psychiatry setting.MethodsWe performed a retrospective cohort study including 275 randomly selected inpatients with medical illness assessed by the psychiatric C-L team of a large Canadian academic hospital between 2008 and 2014. We grouped patients based on whether they were assessed by the C-L team before or after the citalopram Health Canada warning. Our primary outcome was change in citalopram/escitalopram prescribing patterns.ResultsWe found that of patients seen before the Health Canada warning, a significantly higher number were prescribed citalopram/escitalopram (44.1% vs. 22.3%, χ2 = 14.835, p < 0.001), even after controlling for confounders. However, the percentage of patients using a citalopram/escitalopram dose exceeding those recommended by the Health Canada warning was similar in both groups (8.9% vs. 12.1%, χ2 = 0.233, p = 0.63).ConclusionsOverall, C-L psychiatrists were less likely to prescribe citalopram/escitalopram following the Health Canada warning, which did not translate into safer dosing. Clinicians should not avoid prescribing citalopram/escitalopram appropriately in medically vulnerable inpatients when benefits outweigh disadvantages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychosomatics - Volume 57, Issue 1, January–February 2016, Pages 57–63
نویسندگان
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