کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3377749 1220050 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prevalence of and associated factors with chronic kidney disease in human immunodeficiency virus-infected patients in Taiwan
ترجمه فارسی عنوان
شیوع و عوامل مرتبط با بیماری مزمن کلیه در بیماران مبتلا به ویروس نقص ایمنی بدن در تایوان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

BackgroundChronic kidney disease (CKD) is an important issue for individuals who live with human immunodeficiency virus (HIV) following the use of highly active antiretroviral therapy; however, the prevalence rate of CKD varies between countries.MethodsThe present study screened HIV-infected patients in a medical center and a regional teaching hospital in southern Taiwan from January 2008 to December 2012. CKD was defined as a urine microalbumin-to-creatinine ratio ≥30 mg/g, and/or a protein ≥1 + on urine dipstick examination, and/or an estimated glomerular filtration rate <60 mL/min/1.73 m2 for 3 months. The prevalence rate and the analyzed associated factors of CKD were determined.ResultsAmong 1639 HIV-infected patients, only 512 had adequate data to be enrolled in the study. Thirty-six (7.03%) of these patients had CKD, and 476 did not. In a univariate analysis, CKD was associated with an older age, a higher peak HIV RNA load, diabetes mellitus (DM), hypertension, exposure to antiretroviral therapy, and cholesterol levels ≥240 mg/dL. Multivariate analysis revealed that DM, hypertension, and cholesterol ≥240 mg/dL were statistically significant factors.ConclusionIn Taiwan, the prevalence of CKD in HIV-infected patients was low (7.03%). The classical risk factors for CKD, such as DM, hypertension, and hypercholesterolemia, were demonstrated to be associated with CKD in Taiwanese HIV-infected patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Microbiology, Immunology and Infection - Volume 48, Issue 3, June 2015, Pages 256–262
نویسندگان
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