کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3377835 1220054 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Application of minigenome technology in virology research of the Paramyxoviridae family
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Application of minigenome technology in virology research of the Paramyxoviridae family
چکیده انگلیسی

Minigenomes (MGs) are complementary DNAs of the synthetic analogs of genomic RNA. MGs are widely used to study the life cycle of the Paramyxoviridae family of viruses. MG-based studies have provided valuable insights into the mechanisms of viral replication and transcription in this family, including the roles of viral proteins, the location and boundaries of the cis-acting elements, the functional domains of trans-acting proteins, techniques for the measurement of neutralizing antibody, virus–host interactions, and the structure and function of viral RNA. This article provides a brief overview of the principle and application of MG technology in studies involving members of the Paramyxoviridae family. The advantages, potential limitations, and future scope of MG technology are also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Microbiology, Immunology and Infection - Volume 48, Issue 2, April 2015, Pages 123–129
نویسندگان
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