کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3378466 | 1220086 | 2011 | 9 صفحه PDF | دانلود رایگان |
BackgroundTo compare the monotherapy of tigecycline with vancomycin-aztreonam in hospitalized patients from India and Taiwan with complicated skin and skin structure infections (cSSSIs).MethodsSafety and efficacy data were analyzed for Indian (n = 86) and Taiwanese (n = 41) patients hospitalized with cSSSIs who participated in two international Phase 3, randomized, double-blind studies.ResultsPatients were treated for 5–14 days. Cure rates at the test-of-cure assessment (12–92 days post-therapy) were generally similar between tigecycline and vancomycin-aztreonam in the clinically evaluable populations (India, 83.3% vs. 75.8%; Taiwan, 78.6% vs. 90%) and in the clinical modified intent-to-treat populations (India, 78.6% vs. 66.7%; Taiwan, 73.3% vs. 75.0%). Nausea and vomiting occurred more frequently with tigecycline, but overall safety and tolerability were comparable between the two treatments.ConclusionsTigecycline monotherapy is a safe and effective therapy for cSSSIs in geographically distinct populations in Asia.
Journal: Journal of Microbiology, Immunology and Infection - Volume 44, Issue 2, April 2011, Pages 116–124