کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3381263 1220243 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural adaptations in compressed articular cartilage measured by diffusion tensor imaging
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
پیش نمایش صفحه اول مقاله
Structural adaptations in compressed articular cartilage measured by diffusion tensor imaging
چکیده انگلیسی

SummaryObjectiveTo demonstrate the use of diffusion tensor magnetic resonance micro-imaging to observe adaptations of collagen fibres to mechanical compression in articular cartilage.MethodsSpin-echo and diffusion tensor images (156 × 156 μm in-plane resolution, 2 mm slice thickness) of bovine cartilage were obtained at a magnetic field of 7.0 T in relaxed and compressed states. The parameters determined were: T2, maximum and mean diffusivity, direction of the maximum diffusion eigenvector and fractional anisotropy of diffusion.ResultsA correlation was found between the compressive strain applied to the cartilage and the change in both magnitude and direction of the maximum diffusivity. Compression resulted in a decrease in both the maximum and mean eigenvalues, particularly in the surface and transitional zones, while the change in orientation of the eigenvectors corresponding to maximum diffusion was greatest in the transitional region. In this region, the average orientation of the principal eigenvectors with respect to the normal to the articular surface increased by up to 40°, indicating that the collagen fibre bundles were oriented more parallel to the surface when compressed.ConclusionsDiffusion tensor imaging can be used to monitor the changes in the direction of the collagen fibres due to compression. It may form the basis of a new non-invasive approach to functional evaluation of cartilage, with potential applications in the diagnosis and treatment of osteoarthritis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Osteoarthritis and Cartilage - Volume 16, Issue 1, January 2008, Pages 83–89
نویسندگان
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