کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3383393 1220455 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interleucinas en la fisiopatología de la artritis reumatoide: más allá de las citocinas proinflamatorias
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
پیش نمایش صفحه اول مقاله
Interleucinas en la fisiopatología de la artritis reumatoide: más allá de las citocinas proinflamatorias
چکیده انگلیسی
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovitis and progressive destruction of the joint cartilage and underlying bone, together with diverse extra-articular manifestations. Cytokines act as soluble effector mediators of the inflammatory process. Therapeutic neutralization with monoclonal antibodies against the pro-inflammatory cytokines TNF-alpha and interleukin 1 (IL-1) has shown a clear efficacy on inflammation and clinical manifestations of RA, although a percentage of patients do not respond. This review covers new relevant cytokines in the RA physiopathology and potential biomarkers of inflammation. The current challenge is to develop biomarkers that enable an earlier diagnosis, as well as prognostic markers and new therapeutic candidates. Combined administration of several of these cytokines could eventually address a personalized treatment approach for each patient.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reumatología Clínica - Volume 6, Supplement 3, March 2011, Pages 20-24
نویسندگان
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