کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3385474 | 1220599 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pioderma gangrenoso refractario: utilidad de la terapia combinada. Enfoque en beneficio de la terapia hiperbárica en su tratamiento
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ایمونولوژی، آلرژی و روماتولوژی
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چکیده انگلیسی
Pyoderma gangrenosum is a type of neutrophilic dermatosis that has an idiopathic component, or can be associated with other underlying systemic pathologies. It is the result of an exaggerated response against specific and non specific stimuli. The first line of therapy are glucocorticoids (GC); however, in some patients, control of the pathology is not achieve with this treatment (local or systemic), and it is needed a step-up therapy going through several immuno-modulating treatments, biologic agents Anti - TNFα, and in refractory cases, the use of non conventional therapies such as Hyperbaric Oxygen Therapy (THBO). In this case, a previously healthy 42 year old man, debuts with an ulcerated lesion in his right lower limb, and he is initially treated with GC with poor response. He then required the use of several synthetic immune modulators without therapeutic efficacy. We opted to iniciate Anti-TNFα therapy obtaining therapeutic failure with the use of etanercept, infliximab, and adalimumab given in regular drug regimens. Finally, it is modify the frecuency of adalimumab to one dose per week without appropriate response; it is then added micofenolate mofetil, and fifty sessions of THBO, achieving successful control of this pathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Colombiana de ReumatologÃa - Volume 20, Issue 3, September 2013, Pages 171-176
Journal: Revista Colombiana de ReumatologÃa - Volume 20, Issue 3, September 2013, Pages 171-176
نویسندگان
Juan Sebastián Segura Charry, Diego Alejandro Jaimes, John DarÃo Londoño,