Clinical Presentation of Bipolar Mania in HIV-Positive Patients in Uganda

BackgroundSecondary mania in HIV-positive individuals has been well documented; however, cases of bipolar mania in HIV infection occur, as well.ObjectiveThis is the first controlled study of the demographic and clinical characteristics of bipolar mania and secondary mania in persons with HIV/AIDS in Uganda and Africa.MethodPatients were consecutively recruited from the adult psychiatric wards of Makerere University (Uganda) teaching hospitals. Diagnosis of acute manic episode was based on DSM–IV criteria.ResultsThe HIV-positive patients with bipolar mania had more immune suppression and more cognitive impairment, suggesting that these patients may already have been cognitively and functionally impaired by their mental illness by the time they acquired HIV infection.DiscussionThese findings may be used to help clinicians and policymakers recognize and design appropriate interventions for this vulnerable group of patients. Further studies to delineate the phenomenology of mania in patients with HIV infection/AIDS are warranted.