کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3393629 1221353 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical features and diagnosis of 42 travellers with cutaneous leishmaniasis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Clinical features and diagnosis of 42 travellers with cutaneous leishmaniasis
چکیده انگلیسی

SummaryBackgroundLeishmania species that occur within different geographical areas may cause different clinical manifestations, virulence and drug sensitivity. Patients/Methods. All patients with a clinical diagnosis of cutaneous leishmaniasis seen at the Hospital for Tropical Diseases from 1997 to 2000 were identified and clinical details recorded onto a database, with emphasis on clinical presentation, risk factors, travel history and laboratory diagnosis.ResultsForty-two patients were identified, 23 of whom had travelled to New World and 19 to Old World countries. Clinical presentation typically consisted of a single nodule with ulceration. In 50% infection was caused by L. (Viannia) braziliensis.PCR was performed in specimens from 34 patients and species identification was possible in 32 cases (sensitivity 94%), the two PCR negative patients had amastigotes demonstrated by histology and culture.Patients were treated with established therapies. Seventy one percent were cured by treatment, 12% had a spontaneous cure, 7% were lost to follow-up and the remaining 10% required a second-line therapy. No relapses were reported during a mean follow-up period of 27 months.ConclusionsOur study highlights the need for comprehensive investigations and the advantages of PCR in the diagnosis of patients with suspected leishmaniasis in non-endemic regions of the world.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Travel Medicine and Infectious Disease - Volume 4, Issue 1, January 2006, Pages 14–21
نویسندگان
, , , , , , , ,