کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3405744 | 1223479 | 2014 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Surveillance trends of carbapenem-resistant Enterobacteriaceae from Singapore, 2010–2013 Surveillance trends of carbapenem-resistant Enterobacteriaceae from Singapore, 2010–2013](/preview/png/3405744.png)
Trends in carbapenem-resistant Enterobacteriaceae (CRE) collected from hospitals nationwide in Singapore over 3 years are presented. Hospital isolates with imipenem or meropenem minimum inhibitory concentrations (MICs) of >1 mg/L were sent to the National Public Health Laboratory for further investigation. A total of 400 CRE were submitted, 227 (56.8%) of which carried a carbapenemase gene. blaNDM was the most common (130/400; 32.5%), followed by blaOXA-48-like (blaOXA-48, -181, -232) (55/400; 13.8%). Interestingly, four isolates bearing dual carbapenemase genes were also detected. KPC- and OXA-48-like-producing Klebsiella pneumoniae were fingerprinted by DiversiLab® rep-PCR. Locally, KPC producers do not appear to have clonal dissemination. In contrast, OXA-48-like producers were found to have a greater degree of clustering than KPC producers.
Journal: Journal of Global Antimicrobial Resistance - Volume 2, Issue 2, June 2014, Pages 99–102