کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3418605 | 1225747 | 2015 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Weekly irinotecan combined with carboplatin for patients with small-cell lung cancer: A phase I study Weekly irinotecan combined with carboplatin for patients with small-cell lung cancer: A phase I study](/preview/png/3418605.png)
BackgroundWe conducted a phase I dose escalation study to evaluate the feasibility, maximum tolerated dose (MTD), and recommended dose (RD) of weekly irinotecan combined with fixed-dose carboplatin for patients with untreated small-cell lung cancer (SCLC).MethodsFifteen patients with chemotherapy-naïve SCLC less than 75 years old were enrolled from 3 institutions. Patients received irinotecan (50–80 mg/m2 on days 1 and 8) and carboplatin (area under the curve, 5.0 on day 1) every 3 weeks, with 3–6 patients treated at each irinotecan dosage level (levels I–IV). The MTD was defined as the dose at which 33% of patients experienced dose-limiting toxicity.ResultsEleven patients had a performance status of 1, and 7 patients were more than 70 years old. All but 1 patient were diagnosed with extensive disease. In total, 2 of 3 patients enrolled at level IV (80 mg/m2) experienced grade 3 diarrhea. Therefore, the MTD was defined as the level IV dose, and the RD was defined as the level III dose (70 mg/m2). Grade 3 or 4 neutropenia was observed in 60% of patients, and febrile neutropenia was observed in 13% of patients. Four patients experienced grade 3 or 4 anemia, and 6 patients experienced grade 3 or 4 thrombocytopenia. The most common non-hematological adverse events were nausea/vomiting, diarrhea, hypokalemia, and hyponatremia.ConclusionsThe MTD of weekly irinotecan was 80 mg/m2, resulting in an RD of 70 mg/m2 for phase II trials.
Journal: Respiratory Investigation - Volume 53, Issue 4, July 2015, Pages 156–160