کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3431653 | 1594462 | 2014 | 5 صفحه PDF | دانلود رایگان |

BackgroundHypercoagulability in thalassemia especially in thalassemia major has emerged as a complication of the disease. There is evidence of increased platelet aggregation and increased proportion of platelets expressing P-selectin in thalassemia. P-selectin is a cell adhesion molecule which plays a key role in hemostasis and thrombosis, mediating platelet rolling and generating procoagulant molecules. Substance P is one of the tachykinins which constitute a family of neuropeptides. It now appears that platelets contain substance P which is released upon stimulation leading to faster and more extensive aggregation.ObjectiveTo detect the possible role of substance P and soluble P-selectin (sP-selectin) as biomarkers of hypercoagulability in patients with beta-thalassemia major.Subjects and methodsVenous blood samples were collected from ten normal control subjects and thirty patients with beta-thalassemia major (divided into two groups, splenectomized and unsplenectomized). To all studied individuals, plasma substance P and sP-selectin were assayed by an enzyme linked Immunosorbent assay (ELISA).ResultsHigher levels of plasma substance P and sP-selectin were observed in thalassemic patients versus the controls. Both substance P and sP-selectin were significantly higher in the splenectomized group of patients.ConclusionsSubstance P and sP-selectin might have a role in platelet activation and subsequent hypercoagulability in thalassemic patients.
Journal: Alexandria Journal of Medicine - Volume 50, Issue 2, June 2014, Pages 107–111