کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3442460 | 1595021 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Glycodelin mediates the increase in vascular endothelial growth factor in response to oxidative stress in the endometrium Glycodelin mediates the increase in vascular endothelial growth factor in response to oxidative stress in the endometrium](/preview/png/3442460.png)
ObjectiveWe hypothesized that glycodelin stimulates vascular endothelial growth factor (VEGF) expression in response to oxidative stress.Study designEM42 (human endometrial epithelial cell line) and primary endometrial epithelial cells were subjected to oxidative stress with minimally oxidized low density lipoprotein (mLDL). Cells were also incubated with no LDL (control) or native LDL (nLDL). Each condition was incubated with and without glycodelin antibody. Glycodelin and VEGF protein and messenger RNA (mRNA) levels were analyzed. Primary cells were cultured with glycodelin peptide to evaluate the effect on VEGF protein and mRNA.ResultsGlycodelin and VEGF protein and mRNA were higher for cells grown with mLDL (P < .05), while glycodelin antibody attenuated the increase in VEGF protein (P < .01). Glycodelin peptide increased VEGF mRNA and protein (P < .05).ConclusionGlycodelin may act as an autocrine factor within endometriotic implants to increase VEGF expression during oxidative stress.
Journal: American Journal of Obstetrics and Gynecology - Volume 195, Issue 6, December 2006, Pages 1772–1777