کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3443714 1595237 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Statins and hip fracture risk in men: a population-based case-control study
ترجمه فارسی عنوان
خطر استاتین ها و شکستگی لگن در مردان: یک مطالعه مورد شاهدی مبتنی بر جمعیت است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

PurposeTo estimate the association between hydroxymethylglutaryl-CoA inhibitor (statin) use and hip fracture.MethodsWe conducted a population-based case-control study. Cases were 6774 male enrollees in a large managed care organization, aged 45 or more years, with an incident hip fracture from 1997 to 2006. Controls without fracture (n = 6774) were matched to cases on age, race, and medical center. Electronic information on pharmaceutical use was used to identify the dispensing of statins from 1991 forward.ResultsOverall, 1884 (27.8%) cases and 2150 controls (31.7%) used a statin before index date (matched odds ratio [mOR] = 0.81, 95% confidence interval [CI] = 0.74–0.87). Adjustment for comorbidity burden strengthened the magnitude of the overall association (mOR = 0.68, CI = 0.62–0.74). The adjusted association was similar across age groups but was strongest among men aged 80 years or more (mOR = 0.62, CI = 0.54–0.71) and was most pronounced in African Americans (mOR = 0.43, CI = 0.28–0.64). Greater duration of statin use did not alter the odds ratios.ConclusionsThese data add to the growing evidence of a potential protective effect of statin use on bone health. However, these results need to be replicated in a prospective study that can account for confounding by indication which may explain these findings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Epidemiology - Volume 25, Issue 11, November 2015, Pages 844–848
نویسندگان
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