کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3443948 1595241 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cardiovascular correlates of platelet count and volume in the Framingham Heart Study
ترجمه فارسی عنوان
ارتباط قلب و عروق در شمارش و حجم پلاکت در مطالعه قلب فریمینگام
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

PurposePlatelet count and volume are inexpensive, routinely assayed biomarkers associated with cardiovascular health, but specific relationships among platelet indices, cardiovascular risk factors, and disease warrant further investigation. The purpose of this study was to understand associations among platelet count, volume, and 20 cardiovascular health–related variables in the Framingham Heart Study (FHS).MethodsCross-sectional analyses were performed on platelet count and volume associations with cardiovascular health indicators in three FHS cohorts (original n = 964, offspring n = 2699, and third generation n = 2419) using multivariate linear regression analysis. Time-to-event analysis was used for cardiovascular disease–related event incidences using Kaplan-Meier plots and Cox proportional hazards regression adjusted for age and sex.ResultsResults were concordant with the hypothesis that higher platelet counts are associated with less favorable cardiovascular risk profiles, although mean platelet volume associations were weaker. In our analysis, increased platelet count across FHS cohorts was consistently associated with smoking, triglycerides, low-density lipoprotein, and total cholesterol levels. Some associations with platelet count appeared sex dependent.ConclusionsSignificant associations of common blood platelet measurements are observed with sex and cardiovascular risk factors, namely smoking and lipids. Research is warranted to confirm these relationships in other cohorts, evaluate differences by ethnicity, and examine longitudinal effects on disease risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Epidemiology - Volume 25, Issue 7, July 2015, Pages 492–498
نویسندگان
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