کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3444263 1595279 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metabolic Syndrome and 16-Year Cognitive Decline in Community-Dwelling Older Adults
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Metabolic Syndrome and 16-Year Cognitive Decline in Community-Dwelling Older Adults
چکیده انگلیسی

PurposeTo determine whether metabolic syndrome is associated with accelerated cognitive decline in community-dwelling older adults.MethodsA longitudinal study of 993 adults (mean 66.8 ± 8.7 years) from the Rancho Bernardo Study. Metabolic syndrome components, defined by 2001 NCEP-ATP III criteria, were measured in 1984-1987. Cognitive function was first assessed in 1988-1992. Cognitive assessments were repeated approximately every 4 years, for a maximum 16-year follow-up. Mixed-effects models examined longitudinal rate of cognitive decline by metabolic syndrome status, controlling for factors plausibly associated with cognitive function (diabetes, inflammation).ResultsMetabolic syndrome was more common in men than women (14% vs. 9%, p = .01). In women, metabolic syndrome was associated with greater executive function and long-term memory decline. These associations did not differ by inflammatory biomarker levels. Diabetes did not alter the association of metabolic syndrome with long-term recall but modified the association with executive function: metabolic syndrome was associated with accelerated executive function decline in diabetic women only. Metabolic syndrome was not related to rate of decline on any cognitive measure in men.ConclusionsMetabolic syndrome was a risk factor for accelerated cognitive decline, but only in women. Prevention of metabolic syndrome may aid in maintenance of cognitive function with age.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Epidemiology - Volume 22, Issue 5, May 2012, Pages 310–317
نویسندگان
, , , , , , ,