کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3446386 1595467 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of Histaminergic System in Blood–Brain Barrier Dysfunction Associated with Neurological Disorders
ترجمه فارسی عنوان
نقش سیستم هیستمینژیک در خونریزی اختلال مانع مغزی مرتبط با اختلالات عصبی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

Blood–brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outside elements from blood to the central nervous system (CNS) that may trigger a cascade of events that leads to neuroinflammation. In this review, evidence that mast cells and the release of factors such as histamine play an important role in the neuroinflammatory process associated with brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy is presented.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Medical Research - Volume 45, Issue 8, November 2014, Pages 677–686
نویسندگان
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