کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3447745 | 1595518 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Multidrug Resistance-1 in T Lymphocytes and Natural Killer Cells of Adults with Idiopathic Thrombocytopenic Purpura: Effect of Prednisone Treatment
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Multidrug Resistance-1 in T Lymphocytes and Natural Killer Cells of Adults with Idiopathic Thrombocytopenic Purpura: Effect of Prednisone Treatment Multidrug Resistance-1 in T Lymphocytes and Natural Killer Cells of Adults with Idiopathic Thrombocytopenic Purpura: Effect of Prednisone Treatment](/preview/png/3447745.png)
چکیده انگلیسی
High P-glycoprotein-mediated multidrug resistance-1 (P-gp/MDR1) activity in lymphocytes from idiopathic thrombocytopenic purpura (ITP) patients may affect disease outcome. ITP treatment includes glucocorticoids that are substrates of P-gp; hence, P-gp functional activity and antigenic expression were assessed by flow cytometry in T and natural killer (NK) cells from ITP patients before and after prednisone therapy. Herein, patients’ T and NK cells did not show increased MDR1 functional activity, whereas P-gp antigenic expression was significantly enhanced in both therapy-free and prednisone-treated patients. Prednisone treatment did not significantly modify the function and expression of MDR1 in T and NK cells of ITP patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Medical Research - Volume 39, Issue 5, July 2008, Pages 541–545
Journal: Archives of Medical Research - Volume 39, Issue 5, July 2008, Pages 541–545
نویسندگان
Xavier López-Karpovitch, Gerardo Graue, Erick Crespo-Solís, Josefa Piedras,