کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3455159 1596003 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insights into the pyrimidine biosynthetic pathway of human malaria parasite Plasmodium falciparum as chemotherapeutic target
ترجمه فارسی عنوان
مقدمه ای بر مسیر زیستی پیریمیدین از انگل مالاریا انسانی پلاسمودیوم فالسیپاروم به عنوان هدف شیمی درمانی
کلمات کلیدی
مالاریا، پلاسمودیوم فالسیپاروم، مسیر زیستی پیریمیدین، هدف مواد مخدر، توسعه مواد مخدر، شیمی درمانی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

Malaria is a major cause of morbidity and mortality in humans. Artemisinins remain as the first-line treatment for Plasmodium falciparum (P. falciparum) malaria although drug resistance has already emerged and spread in Southeast Asia. Thus, to fight this disease, there is an urgent need to develop new antimalarial drugs for malaria chemotherapy. Unlike human host cells, P. falciparum cannot salvage preformed pyrimidine bases or nucleosides from the extracellular environment and relies solely on nucleotides synthesized through the de novo biosynthetic pathway. This review presents significant progress on understanding the de novo pyrimidine pathway and the functional enzymes in the human parasite P. falciparum. Current knowledge in genomics and metabolomics are described, particularly focusing on the parasite purine and pyrimidine nucleotide metabolism. These include gene annotation, characterization and molecular mechanism of the enzymes that are different from the human host pathway. Recent elucidation of the three-dimensional crystal structures and the catalytic reactions of three enzymes: dihydroorotate dehydrogenase, orotate phosphoribosyltransferase, and orotidine 5′-monophosphate decarboxylase, as well as their inhibitors are reviewed in the context of their therapeutic potential against malaria.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Medicine - Volume 9, Issue 6, June 2016, Pages 525–534
نویسندگان
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